H3034

Sigma

 

Anti-Histone Deacetylase 3 (HDAC3) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

MDL number:MFCD02096545

Description

Immunogensynthetic peptide corresponding to amino acids 411-428 of human and chicken HDAC3.
Physical formSolution in 0.01 M phosphate bufffered saline, pH 7.4, containing 15 mM sodium azide.

Properties

antibody formIgG fraction of antiserum
clone(polyclonal)
formbuffered aqueous solution
mol wtantigen mol wt 50 kDa
species reactivityrat, human, mouse
application(s)immunoblotting: 1:10,000 using nuclear extract from HeLa human epithelioid carcinoma cells
 immunoblotting: 1:2,000 using whole extract of PC-12 rat pheochromocytoma cell line
 immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human lymph node sections
 immunoprecipitation: 1:2,500 using whole lysate of NIH3T3 cells
 microarray: suitable
Gene Informationhuman ... HDAC3(8841)
 rat ... Hdac3(84578)
 mouse ... Hdac3(15183)
shipped indry ice
storage temp.−20°C

Safety

WGK GermanyNWG

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References

referenceAramori, I., et al., Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression. Biochem. Pharmacol. 74, 465-476, (2007) Abstract
 Banayo, E., et al., Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc. Natl. Acad. Sci. U. S. A. 101, 4047-4052, (2004) Abstract